BMS-P5 free base

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

BMS-P5 游离碱是一种具有口服活性的特异性肽基精氨酸脱亚胺酶 4 (PAD4) 抑制剂。 BMS-P5 阻止中性粒细胞胞外陷阱的形成并延缓多发性骨髓瘤的进展。

BMS-P5 free base is a specific and orally active peptidylarginine deiminase 4 (PAD4) inhibitor.?BMS-P5 Blocks Formation of Neutrophil Extracellular Traps and Delays Progression of Multiple Myeloma.?Administration of BMS-P5 to multiple myeloma-bearing mice delays appearance of symptoms and disease progression Targeting PAD4 may be beneficial for treatment of multiple myeloma.Administration of BMS-P5 to multiple myeloma-bearing mice delays appearance of symptoms and disease progression.?

Cell Viability Assay.Cell Line:Neutrophils.Concentration:10 μM and 100 μM.Incubation Time:30 min followed by addition of DP42 or 5TGM1 CM.Result:Prevented MM-induced NET formation.

Animal Model:Syngeneic mouse model of MM.Dosage:50 mg/kg.Administration:Oral gavage, twice a day beginning on day 3 after tumor cell injection.Result:Significantly delayed development of symptoms and significantly prolonged survival of MM-bearing mice.

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Others

Other Targets

peptidylarginine deiminase 4 (PAD4)

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1550371-22-6

472.58

C27H32N6O2

>98% (HPLC)

In Vitro:?DMSO : 250 mg/mL (529.01 mM)

O=C(N1[C@@H](C)CC[C@@H](N)C1)C2=CC(OC)=C3C(N=C(C4=CC5=CC=CN=C5N4CC6CC6)N3C)=C2

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(-20℃)

With Ice Pack

≥ 2 years